SrasV1, Main, Exploration, bibRecord, 000227

Should we expect neurological symptoms in the SARS-CoV-2 epidemic?☆

Identifieur interne : 000227 ( Main/Exploration ); précédent : 000226; suivant : 000228

Should we expect neurological symptoms in the SARS-CoV-2 epidemic?☆

Auteurs : J. Matías-Guiu ; U. Gomez-Pinedo ; P. Montero-Escribano ; P. Gomez-Iglesias ; J. Porta-Etessam ; J. A. Matias-Guiu

Source :

Neurología (English Edition) [ 2173-5808 ] ; 2020.

RBID : PMC:7164915

Abstract

Introduction

There is growing evidence that SARS-CoV-2 can gain access to the central nervous system (CNS). We revise the literature on coronavirus infection of the CNS associated with neurological diseases.

Development

Neurological symptoms were rarely reported in the SARS-CoV and MERS-CoV epidemics, although isolated cases were described. There are also reports of cases of neurological symptoms associated with CoV-OC43 and CoV-229E infection. The presence of neurological lesions, especially demyelinating lesions in the mouse hepatitis virus model, may explain the mechanisms by which coronaviruses enter the CNS, particularly those related with the immune response. This may explain the presence of coronavirus in patients with multiple sclerosis. We review the specific characteristics of SARS-CoV-2 and address the question of whether the high number of cases may be associated with greater CNS involvement.

Conclusion

Although neurological symptoms are not frequent in coronavirus epidemics, the high number of patients with SARS-CoV-2 infection may explain the presence of the virus in the CNS and increase the likelihood of early- or delayed-onset neurological symptoms. Follow-up of patients affected by the SARS-CoV-2 epidemic should include careful assessment of the CNS.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164915

DOI: 10.1016/j.nrleng.2020.03.002
PubMed: NONE
PubMed Central: 7164915

Affiliations:

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<front><div type="abstract" xml:lang="en"><sec><title>Introduction</title>
<p>There is growing evidence that SARS-CoV-2 can gain access to the central nervous system (CNS). We revise the literature on coronavirus infection of the CNS associated with neurological diseases.</p>
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<sec><title>Development</title>
<p>Neurological symptoms were rarely reported in the SARS-CoV and MERS-CoV epidemics, although isolated cases were described. There are also reports of cases of neurological symptoms associated with CoV-OC43 and CoV-229E infection. The presence of neurological lesions, especially demyelinating lesions in the mouse hepatitis virus model, may explain the mechanisms by which coronaviruses enter the CNS, particularly those related with the immune response. This may explain the presence of coronavirus in patients with multiple sclerosis. We review the specific characteristics of SARS-CoV-2 and address the question of whether the high number of cases may be associated with greater CNS involvement.</p>
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<sec><title>Conclusion</title>
<p>Although neurological symptoms are not frequent in coronavirus epidemics, the high number of patients with SARS-CoV-2 infection may explain the presence of the virus in the CNS and increase the likelihood of early- or delayed-onset neurological symptoms. Follow-up of patients affected by the SARS-CoV-2 epidemic should include careful assessment of the CNS.</p>
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Should we expect neurological symptoms in the SARS-CoV-2 epidemic?☆

Should we expect neurological symptoms in the SARS-CoV-2 epidemic?☆

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Abstract

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